Richard T Marconi Selected Research

Complement Factor H (Factor H)

1/2024	Borreliella burgdorferi factor H-binding proteins are not required for serum resistance and infection in mammals.
4/2012	Structure of factor H-binding protein B (FhbB) of the periopathogen, Treponema denticola: insights into progression of periodontal disease.
5/2008	Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction.
8/2006	Immunological and molecular analyses of the Borrelia hermsii factor H and factor H-like protein 1 binding protein, FhbA: demonstration of its utility as a diagnostic marker and epidemiological tool for tick-borne relapsing fever.
4/2006	Molecular analyses of the interaction of Borrelia hermsii FhbA with the complement regulatory proteins factor H and factor H-like protein 1.
3/2006	Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis.
11/2005	Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.
2/2005	Putative coiled-coil structural elements of the BBA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site.
12/2004	Demonstration of the involvement of outer surface protein E coiled coil structural domains and higher order structural elements in the binding of infection-induced antibody and the complement-regulatory protein, factor H.
5/2004	Identification and characterization of a linear-plasmid-encoded factor H-binding protein (FhbA) of the relapsing fever spirochete Borrelia hermsii.

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Richard T Marconi Research Topics

Disease

30	Infections 01/2024 - 08/2002
23	Lyme Disease (Disease, Lyme) 01/2024 - 06/2003
9	Relapsing Fever 11/2016 - 08/2003
6	Periodontal Diseases (Periodontal Disease) 01/2021 - 11/2005
5	Anaplasmosis 12/2022 - 08/2014
1	Leptospirosis 12/2023
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2022
1	Coinfection 12/2020
1	Scrub Typhus (Typhus, Scrub) 06/2018
1	Abscess 07/2016
1	Periodontitis 04/2012

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 01/2024 - 08/2002
12	Complement Factor H (Factor H)IBA 01/2024 - 06/2003
10	VaccinesIBA 01/2021 - 12/2005
9	1-oleoyl-2-stearoylphosphatidylcholineIBA 01/2020 - 12/2005
8	EpitopesIBA 07/2019 - 08/2002
6	Carrier Proteins (Binding Protein)IBA 01/2024 - 06/2003
6	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020 - 12/2004
5	Complement System Proteins (Complement)IBA 01/2024 - 08/2003
4	OspC proteinIBA 01/2019 - 12/2005
4	LigandsIBA 02/2015 - 11/2007
3	Subunit VaccinesIBA 12/2023 - 01/2017
3	Lipoproteins (Lipoprotein)IBA 10/2022 - 06/2011
3	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 12/2005
3	bis(3',5')-cyclic diguanylic acidIBA 01/2018 - 07/2011
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2022 - 07/2015
2	AntibodiesIBA 12/2020 - 10/2009
2	Protein Disulfide-IsomerasesIBA 01/2020 - 01/2020
2	DisulfidesIBA 01/2020 - 01/2020
2	diguanylate cyclaseIBA 11/2016 - 07/2011
2	Blood Proteins (Serum Proteins)IBA 05/2008 - 03/2006
1	Endosomal Sorting Complexes Required for TransportIBA 12/2022
1	Karyopherins (Importin)IBA 01/2021
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2021
1	LipidsIBA 10/2020
1	Oxidoreductases (Dehydrogenase)IBA 01/2020
1	OMPA outer membrane proteinsIBA 01/2020
1	EnzymesIBA 01/2020
1	tris(2-carboxyethyl)phosphineIBA 01/2020
1	amixicileIBA 12/2018
1	Polysaccharides (Glycans)IBA 01/2017
1	Monoclonal AntibodiesIBA 01/2017
1	AntigensIBA 01/2017
1	OspA proteinIBA 01/2017
1	Immunoglobulin G (IgG)IBA 12/2016
1	Histidine KinaseIBA 11/2016
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 11/2016
1	Peptide Hydrolases (Proteases)FDA Link 07/2016
1	dentilisinIBA 07/2016
1	F-Box ProteinsIBA 10/2015
1	Protein SIBA 10/2015
1	cefovecinIBA 07/2015
1	Amoxicillin (Wymox)FDA LinkGeneric 07/2015
1	Doxycycline (Periostat)FDA LinkGeneric 07/2015
1	SugarsIBA 02/2015
1	P-SelectinIBA 02/2015
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 02/2015
1	Glycoproteins (Glycoprotein)IBA 02/2015
1	FucoseIBA 02/2015
1	Sialyl Lewis X AntigenIBA 02/2015
1	Immune Sera (Antisera)IBA 08/2014
1	Salivary Proteins and PeptidesIBA 08/2011
1	Green Fluorescent ProteinsIBA 07/2011
1	PlasminogenIBA 05/2008
1	A-factor (Streptomyces)IBA 08/2006
1	Methylnitronitrosoguanidine (MNNG)IBA 12/2005
1	DNA (Deoxyribonucleic Acid)IBA 01/2005

Therapy/Procedure

1	Oral Administration 07/2015